two-dimensional principle component analysis (pca) (Partek)
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Two Dimensional Principle Component Analysis (Pca), supplied by Partek, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
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1) Product Images from "Identification of Identical Transcript Changes in Liver and Whole Blood during Acetaminophen Toxicity"
Article Title: Identification of Identical Transcript Changes in Liver and Whole Blood during Acetaminophen Toxicity
Journal: Frontiers in Genetics
doi: 10.3389/fgene.2012.00162
Figure Legend Snippet: Principle component analysis (PCA) and hierarchical cluster analysis (HCA) of the test animal set at 6 h post dose . The 760 probes identified in the training animal as co-regulated in liver and blood at 6 h (patterns 3 and 4 in Figure B) reasonably distinguished the animals receiving the subtoxic dose from those receiving toxic doses. Cy3 and Cy5 array results were averaged for each rat so each symbol represents a single animal. (A) Liver PCA result; (B) Blood PCA result; (C) Liver HCA result; (D) . Blood HCA result. For HCA, samples were grouped by Euclidean distance and average linkage. Legends for (A,B) : circle, subtoxic; Triangle, toxic. Legends for (C,D) Red, subtoxic; Blue, toxic.
Techniques Used:
Figure Legend Snippet: Principle component analysis (PCA) and hierarchical cluster analysis (HCA) of test animal set at 24 h post dose . The 185 probes identified to be co-regulated in liver and blood in the training animal set (patterns 3 and 4 in Figure ) generally separated animals without liver injury [ALT < 100; circle and diamond in (A,B) ; red and blue in (C,D) ] from those with liver injury [ALT 200-12, 000; triangle in (A,B) ; green in (C,D) ] but had a poor classification of exposure levels, categorized as subtoxic dose [circle in (A,B) , red in (A,B) ] and toxic dose [diamond and triangle in (A,B) , blue and green in (C,D) ] in both liver (A,B) and blood (A,B) . (A) Liver PCA result; (B) Blood PCA result; (C) . Liver HCA result; (D) . Blood HCA result. For HCA, samples were grouped by Euclidean distance and average linkage. Legends for (A,B) : circle, subtoxic dose; diamond, toxic dose without liver injury; Triangle, toxic dose with liver injury. Legends for (A,B) : red, subtoxic dose; Blue, toxic dose without liver injury; Green, toxic dose with liver injury.
Techniques Used: